Health & Medicine
Researchers Help Eliminate Plin2 Gene in Mice to Stop Obesity, Could also be Used in Humans
Kathleen Lees
First Posted: Mar 05, 2013 12:29 PM EST
Researchers found that eliminating certain genes in mice can help stop obesity that could possibly help humans.
Through deleting this specific gene, researchers have discovered that it can prevent mice from becoming obese even on a high fat diet.
"When fed a diet that induces obesity these mice don't get fat," said Prof. James McManaman, Ph.D., lead author of the study and vice-chairman of research for Obstetrics and Gynecology at the University of Colorado School of Medicine. "It may be possible to duplicate this in humans using existing technology that targets this specific gene."
The two-year study, funded by the National Institutes of Health and the U.S. Department of Agriculture, was published last month in the Journal of Lipid Research.
The research team created a strain of mice with the Plin2 gene, which produces a protein that regulates fat storage and metabolism. They, in turn, immediately found that mice were resistant to obesity through wanting to eat less and be more active.
The study notes that the fat cells were also 20 percent smaller than typical mice and did not show the kind of inflammation usually associated with obesity.
Obesity-associated fatty liver disease, common in obese humans and rodents, was absent in the mice without the Plin2 gene.
"The mice were healthier," McManaman said. "They had lower triglyceride levels, they were more insulin-sensitive, they had no incidents of fatty liver disease and there was less inflammation in the fat cells."
The absence of the gene may cause fat to be metabolized faster, he said.
"Now we want to know why this works physiologically," McManaman said. "We want to better understand how this affects food consumption."
According to the study, understanding how Plin2 is involved in the control of energy balance will provide new insights into "the mechanisms by which nutrition overload is detected, and how individuals adapt to, or fail to adapt to, dietary challenges."
The consequences for people are highly significant since they also possess the Plin2 gene.
"It could mean that we have finally discovered a way to disrupt obesity in humans," he said. "That would be a major breakthrough."
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First Posted: Mar 05, 2013 12:29 PM EST
Researchers found that eliminating certain genes in mice can help stop obesity that could possibly help humans.
Through deleting this specific gene, researchers have discovered that it can prevent mice from becoming obese even on a high fat diet.
"When fed a diet that induces obesity these mice don't get fat," said Prof. James McManaman, Ph.D., lead author of the study and vice-chairman of research for Obstetrics and Gynecology at the University of Colorado School of Medicine. "It may be possible to duplicate this in humans using existing technology that targets this specific gene."
The two-year study, funded by the National Institutes of Health and the U.S. Department of Agriculture, was published last month in the Journal of Lipid Research.
The research team created a strain of mice with the Plin2 gene, which produces a protein that regulates fat storage and metabolism. They, in turn, immediately found that mice were resistant to obesity through wanting to eat less and be more active.
The study notes that the fat cells were also 20 percent smaller than typical mice and did not show the kind of inflammation usually associated with obesity.
Obesity-associated fatty liver disease, common in obese humans and rodents, was absent in the mice without the Plin2 gene.
"The mice were healthier," McManaman said. "They had lower triglyceride levels, they were more insulin-sensitive, they had no incidents of fatty liver disease and there was less inflammation in the fat cells."
The absence of the gene may cause fat to be metabolized faster, he said.
"Now we want to know why this works physiologically," McManaman said. "We want to better understand how this affects food consumption."
According to the study, understanding how Plin2 is involved in the control of energy balance will provide new insights into "the mechanisms by which nutrition overload is detected, and how individuals adapt to, or fail to adapt to, dietary challenges."
The consequences for people are highly significant since they also possess the Plin2 gene.
"It could mean that we have finally discovered a way to disrupt obesity in humans," he said. "That would be a major breakthrough."
See Now: NASA's Juno Spacecraft's Rendezvous With Jupiter's Mammoth Cyclone