Health & Medicine
Direct Link Between Women's Reproductive Ability's and Immune Status
Kathleen Lees
First Posted: May 17, 2013 02:16 PM EDT
A new study shows that women's reproductive functions may be linked to their immune status.
Previous studies have found this association in human males, but not females.
According to University of Illinois anthropology professor Kathryn Clancy, the lead researcher of the study, the body's first priority is dedicated. Any leftover energy is given to reproduction. There is a balance between resource allocation to maintenance and reproductive efforts, and environmental stressors can lessen available resources, said Clancy, who co-directs the Laboratory for Evolutionary Endocrinology at Illinois.
Study participants consisted of healthy, premenopausal, rural Polish women who participate in traditional farming practices. Researchers collected the women's urine and saliva samples during the harvest season, when physical activity levels are at their peak. This physical work constrains available energetic resources. Previous studies showed that the highest levels of ovarian suppression occurred during the harvest season, according to a press release.
Researchers measured participants' salivary ovarian hormone levels daily over one menstrual cycle. They also tested urine samples for levels of C-reactive protein (CRP), a commonly used marker of inflammation.
"Depending on the other factors that you look at alongside it, CRP can tell you about immune function or it can tell you about psychosocial stress, because CRP has been correlated to both of those things in other populations," Clancy said, according to a press release.
Researched looked at the negative relationship between CRP and progesterone in the Polish women - in women with high CRP, progesterone levels were low. Researchers also found that estradiol and the age of first menstruation were the strongest predictors of CRP levels.
Clancy noted that it is too early to tell whether these correlational relationships indicate a causal relationship in which inflammation suppresses ovarian hormones. However, she believes that there are two possible pathways that explain these results.
"One is that there is an internal mechanism, and this local inflammation drives higher levels of CRP, and that is what's correlating with the lower progesterone," she said. "The other possibility is that there is an external stressor like psychosocial or immune stress driving allocation to maintenance effort, which in turn is suppressing ovarian hormones."
Clancy believes that her research will help women "understand their bodies better."
"From an anthropological perspective, these trade-offs are really important because they help us understand the timing of different life events: Why does someone hit puberty when they do, why do they begin reproducing when they do, why do they space babies the way they do?" Clancy said.
"It's really interesting to see the interplay between a person's intentions about when and why to have children, and then their own body's allocations to reproduction or not," Clancy said.
The study appears in the American Journal of Human Biology.
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First Posted: May 17, 2013 02:16 PM EDT
A new study shows that women's reproductive functions may be linked to their immune status.
Previous studies have found this association in human males, but not females.
According to University of Illinois anthropology professor Kathryn Clancy, the lead researcher of the study, the body's first priority is dedicated. Any leftover energy is given to reproduction. There is a balance between resource allocation to maintenance and reproductive efforts, and environmental stressors can lessen available resources, said Clancy, who co-directs the Laboratory for Evolutionary Endocrinology at Illinois.
Study participants consisted of healthy, premenopausal, rural Polish women who participate in traditional farming practices. Researchers collected the women's urine and saliva samples during the harvest season, when physical activity levels are at their peak. This physical work constrains available energetic resources. Previous studies showed that the highest levels of ovarian suppression occurred during the harvest season, according to a press release.
Researchers measured participants' salivary ovarian hormone levels daily over one menstrual cycle. They also tested urine samples for levels of C-reactive protein (CRP), a commonly used marker of inflammation.
"Depending on the other factors that you look at alongside it, CRP can tell you about immune function or it can tell you about psychosocial stress, because CRP has been correlated to both of those things in other populations," Clancy said, according to a press release.
Researched looked at the negative relationship between CRP and progesterone in the Polish women - in women with high CRP, progesterone levels were low. Researchers also found that estradiol and the age of first menstruation were the strongest predictors of CRP levels.
Clancy noted that it is too early to tell whether these correlational relationships indicate a causal relationship in which inflammation suppresses ovarian hormones. However, she believes that there are two possible pathways that explain these results.
"One is that there is an internal mechanism, and this local inflammation drives higher levels of CRP, and that is what's correlating with the lower progesterone," she said. "The other possibility is that there is an external stressor like psychosocial or immune stress driving allocation to maintenance effort, which in turn is suppressing ovarian hormones."
Clancy believes that her research will help women "understand their bodies better."
"From an anthropological perspective, these trade-offs are really important because they help us understand the timing of different life events: Why does someone hit puberty when they do, why do they begin reproducing when they do, why do they space babies the way they do?" Clancy said.
"It's really interesting to see the interplay between a person's intentions about when and why to have children, and then their own body's allocations to reproduction or not," Clancy said.
The study appears in the American Journal of Human Biology.
See Now: NASA's Juno Spacecraft's Rendezvous With Jupiter's Mammoth Cyclone