Health & Medicine
Antibody can Isolate Stem Cells from Umbilical Cord Blood
Kathleen Lees
First Posted: Sep 03, 2013 05:19 PM EDT
A recent study shows that a new recombinant antibody may be able to detect and isolate mesenchymal stem cells (MSCs) via a nonembryonic source of stem cells with promising applications in tissue engineering, blood stem cell transplantation and treatments for immune-mediated disorders.
Background information from the study notes that the antibody is recognized via a I blood group antigen that presents on MSCs through umbilical cord blood.
Coauthors from the Finnish Red Cross Blood Service and VTT Technical Research Center of Finland worked to identify a blood donor with high levels of the antibody in the blood group antigen.
The authors elaborate on information regarding the I antigen and how it can serve as a marker to detect and isolate MSCs in the umbilical cord blood (UCB) as described via the use of the antibody phage display technology to produce recombinant anti-I antibody that recognizes the I antigen on the surface of UCB-MSCs as well as via red blood cells.
"The authors have used antibody phage display technology to generate an anti-i antibody," BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland said, via a press release. "The advantage of this technique is that antibodies against poorly immunogenic molecules can be generated, as an immunization strategy is not required. The availability of an anti-i antibody has the potential to improve the isolation efficiency of MSCs from umbilical cord blood samples."
What do you think?
More information regarding the study can be found via BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc.
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First Posted: Sep 03, 2013 05:19 PM EDT
A recent study shows that a new recombinant antibody may be able to detect and isolate mesenchymal stem cells (MSCs) via a nonembryonic source of stem cells with promising applications in tissue engineering, blood stem cell transplantation and treatments for immune-mediated disorders.
Background information from the study notes that the antibody is recognized via a I blood group antigen that presents on MSCs through umbilical cord blood.
Coauthors from the Finnish Red Cross Blood Service and VTT Technical Research Center of Finland worked to identify a blood donor with high levels of the antibody in the blood group antigen.
The authors elaborate on information regarding the I antigen and how it can serve as a marker to detect and isolate MSCs in the umbilical cord blood (UCB) as described via the use of the antibody phage display technology to produce recombinant anti-I antibody that recognizes the I antigen on the surface of UCB-MSCs as well as via red blood cells.
"The authors have used antibody phage display technology to generate an anti-i antibody," BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland said, via a press release. "The advantage of this technique is that antibodies against poorly immunogenic molecules can be generated, as an immunization strategy is not required. The availability of an anti-i antibody has the potential to improve the isolation efficiency of MSCs from umbilical cord blood samples."
What do you think?
More information regarding the study can be found via BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc.
See Now: NASA's Juno Spacecraft's Rendezvous With Jupiter's Mammoth Cyclone