Mysterious Gene Influences Cardiovascular Health

Researchers at the University of Ottawa Heart Institute (UOHI) have recently discovered a mysterious gene that may influence cardiovascular health. As the study authors further examine how the genetic variant works, they believe that it contributes to the development of heart issues by promoting inflammation and cell division.

According to researchers at the Ruddy Canadian Cardiovascular Genetics Center, they originally discovered the variant in the gene years ago, known as SPG7. Though it was pegged as a potential contributor to coronary artery disease, other health issues that affect heart health could not be excluded at the time. 

The study notes the following, courtesy of a press release: "SPG7 requires a partner protein to activate itself and start this breakdown process. But, in people who carry the genetic variant in question, SPG7 can activate itself in certain circumstances, leading to increased production of free radicals and more rapid cell division. These factors contribute to inflammation and atherosclerosis."

Senior study author and principal investigator in the Ruddy Canadian Cardiovascular Genetics Center, Dr. Stewart, further discusses the variants role regarding inflammation.

"We think this variant would definitely heighten the state of inflammation, and we know that inflammation affects diabetes and heart disease," Stewart said, via the release. "Interestingly, the variant also makes people more resistant to the toxic side effects of some chemotherapy drugs."

As 13 to 15 percent of people of European decent possess the variant, researchers said they believe these findings could provide a stable switch in regulating inflammation.

"The idea of mitochondria contributing to inflammation isn't new," Stewart concluded, via the release. "But what is new is that we've found one of the switches that regulate this process. We're excited, because once you know where the switches are, you can start looking for ways to turn them on and off."

More information regarding the findings can be seen via the journal Cell Reports.