High Cholesterol Release Switch Discovered

High blood cholesterol is a major risk factor for heart disease and stroke. It can lead to a build-up of plaque in the artery walls and narrowing of the arteries, causing a condition called atherosclerosis which can make it more difficult for blood to flow through the heart and body.

But the Canadian scientists have discovered that a protein called resistin, secreted by fat tissue, causes high levels of "bad" cholesterol increasing the risk of heart disease.

This research proves that resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. Due to which the liver is not able to completely clear the "bad" cholesterol from the body.

Resistin is known for increasing the accumulation of LDL in arteries, increasing the risk of heart disease.

Through the study the researchers have shown how resistin impacts the effects of statins. Stanins are the main cholesterol reducing drug used to treat and prevent cardiovascular disease.

Dr. Shirya Rashid the senior author of the study and assistant professor in the department of medicine at McMaster University, an incredible 40 percent of people taking statins are resistant to their impact on lowering blood LDL.

 "The bigger implication of our results is that high blood resistin levels may be the cause of the inability of statins to lower patients' LDL cholesterol," says Dr. Rashid

 According to the researcher this new discovery opens gates for new therapeutic drugs.

"The possibilities for improved therapy for the causes of cardiovascular disease are very important," says Heart and Stroke Foundation spokesperson Dr. Beth Abramson. "About 40 per cent of Canadians have high blood cholesterol levels: it's a significant health concern in Canada."

 This new discovery highlights the importance of maintaining a healthy weight and cholesterol level, the two important factors in preventing heart disease. Because being overweight triggers the likelihood of high blood pressure and diabetes, causing heart disease and stroke.

 "Fortunately, we know a great deal about heart disease prevention and how to reverse some of the risks," says Dr. Abramson. She urges Canadians to maintain their heart health through regular visits to their doctor, monitoring their weight and waist size, eating a variety of nutritious, low-fat foods and being physically active. "It's equally important to take your medications as directed by your physician to help further reduce risks."