DNA Mystery Solved: Molecules Taken Off Double Helix Structure Possible

DNA X-files mystery have been found to have a significant role in the repair and recreation of human DNA, one that is crucial for every life form. Based on a new research by scientists at the University of Sheffield, it was discovered that branched DNA molecules can be taken off from the popular double-helical structure, a procedure which they have been trying to unlock for more than 20 years.

Based on the DNA X-files episode, Agent Scully inferred that the aliens have inserted branched DNA in her blood, but in real life, these are developed in the human bodies every day, as it occurs whenever body cells divide. According to Functional Genomics Professor and lead author Jon Sayers of the University of Sheffieldn, these branches are significant intermediates that are formed during the process of replicating the DNA.

In a never-before seen photo, the interdisciplinary team from the University of Sheffield's Departments of Infection, Immunity and Cardiovascular Disease, and Molecular Biology and Biotechnology, was able to capture an image of the molecular events in a remarkable  detail. They were able to show how Flap EndoNuclease enzymes, FENs, shape branched DNA molecules once the cells have been divided.

From these, the scientists discovered the FEN threads,  the free end of the branch through a hole in the enzyme prior to sliding along to the trunk where it moves like a pair of molecular secateurs, shaping the branch and repairing the popular double-helix. The team's discovery was done through the Diamond Light Source,  the UK's synchrotron that works like a huge using the energy of electrons to create bright X-ray light that can be used to examine anything from jet engines and fossils to vaccines and viruses,  Daily Galaxy reported.

According to co-author Dr. John Rafferty of the University of Sheffield, the details on how cells have developed to put everything in order have been revealed, eliminating the danger of destructive mutations. Rafferty also added that this information is key to better understanding the cells and determine how to treat the cells where things go wrong sometimes, Wired reported.

DNA X-Files study is published in Natural Structureal & Molecular Biology.